cfDNA PPV Calculator

cfDNA PPV Calculator

0.0 663.00KB 0 Free
Version 1.0 Updated 2026-02-17 Developer David Deschamps

Description

This Cell Free Fetal DNA PPV Calculator estimates positive predictive value (PPV) and negative predictive value (NPV) for prenatal cell-free DNA (cfDNA) screening using Bayesian probability

This Cell Free Fetal DNA PPV Calculator estimates positive predictive value (PPV) and negative predictive value (NPV) for prenatal cell-free DNA (cfDNA) screening using Bayesian probability.

Conditions supported:
• Trisomy 21
• Trisomy 18
• Trisomy 13
• Monosomy X (45,X)
• 47,XXY
• 47,XYY
• 47,XXX

For autosomal trisomies, pretest probability may be derived from maternal-age population risk tables (midtrimester risk by age at term). For sex chromosome aneuploidies, pretest probability can be entered as population prevalence (1 in N). Sensitivity and specificity are user-editable to reflect lab-specific performance.

This app is for screening support and educational use. It does not provide a diagnosis. Positive screening results should be confirmed with diagnostic testing and clinical correlation.
Category: () Version: 1.0 BundleId: com.daviddeschamps.ppvcalculator Developer: David Deschamps Updated: 2026-02-17

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